Not a comment on the interplay, but Japan is well within WHO guidelines for sugars. In school, I heard that Japan reduced gastric cancer cases by 50% when salt intake reduced by 10%. Probably can’t repeat that same public health success again, but with nearly 5m individuals, the effect is strong. I’m not aware of as big a meta analysis for fructose.

https://pubmed.ncbi.nlm.nih.gov/34957192/